Nitrazepam has long been related to serious hepatic Problems, similar to other nitrobenzodiazepines. Nitrobenzodiazepines such as nitrazepam, nimetazepam, flunitrazepam, and clonazepam tend to be more harmful to the liver than other benzodiazepines as they are metabolically activated by CYP3A4 which may result in cytotoxicity.The fifty percent-life